Darren Lee Holmes
- Bats Right, Throws Right
- Height 6' 0", Weight 199 lb.
- High School T. C. Roberson High School
- Debut September 1, 1990
- Final Game September 27, 2003
- Born April 25, 1966 in Asheville, NC USA
Darren Holmes was signed as a 16th round pick in the 1984 amateur draft by the Los Angeles Dodgers and scout Jim Garland. He was the first closer in the history of the Colorado Rockies, saving 25 games in 1993 after being drafted from the Milwaukee Brewers in the expansion draft.