Guido John Grilli
- Bats Left, Throws Left
- Height 6' 0", Weight 188 lb.
- School University of Memphis
- High School Christian Brothers High School (Memphis)
- Debut April 12, 1966
- Final Game July 24, 1966
- Born January 9, 1939 in Memphis, TN USA
Grilli was the first of three big-league players (through 2008) with the last name "Grilli". He came out of the University of Memphis, the second major leaguer to do so. He is the only big-leaguer, however, remembered with the first name "Guido", although Wedo Martini's real name was Guido.